Increased chromosome abnormalities in human preimplantation embryos after in-vitro fertilization in patients with recurrent miscarriage

dc.contributor	Pellicer, A
dc.contributor	Parrilla, JJ
dc.contributor	Moreno, C
dc.contributor	Gimenez, C
dc.contributor	Vidal, F
dc.contributor	Rubio, C
dc.contributor	Simon, C
dc.date.accessioned	2012-01-30T10:04:26Z
dc.date.available	2012-01-30T10:04:26Z
dc.date.issued	1998
dc.identifier.citation	Rep. Fert. Dev. (1998) 10(1): 87-92
dc.identifier.issn	1031-3613
dc.identifier.uri	http://livestocklibrary.com.au/handle/1234/16271
dc.description.abstract	Recurrent miscarriage is a pathological condition induced by maternal andembryonic causes. This paper describes a prospective study to determine thereal incidence of aneuploidy for autosomes 13, 16, 18, 21, 22, and gonosomesin preimplantation human embryos obtained from patients with recurrentpregnancy loss after ovarian stimulation in an IVF-ET programme. Our resultsindicate that aneuploidy for the chromosomes analysed are abnormally higher inembryos obtained after IVF from recurrent abortion patients (58%)compared to non-recurrent abortion patients undergoing IVF. Furthermore,monosomies are six times more frequent than trisomies (47 : 8) inpreimplantation embryos from recurrent abortion patients. Based on the presentstudy, preimplantation genetic diagnosis (PGD) of embryos obtained frompatients with recurrent miscarriage could prove advantageous in diagnosingabnormal embryos and selecting normal embryos for transfer.
dc.publisher	CSIRO Publishing
dc.source.uri	http://www.publish.csiro.au/?act=view_file&file_id=R98030.pdf
dc.subject	habitual abortion
dc.subject	aneuploidy
dc.subject	embryonicabnormalities
dc.title	Increased chromosome abnormalities in human preimplantation embryos after in-vitro fertilization in patients with recurrent miscarriage
dc.type	Research
dc.description.version	Journal article
dc.identifier.volume	10
dc.identifier.page	87-92
dc.identifier.issue	1