Abstract:
Recurrent miscarriage is a pathological condition induced by maternal andembryonic causes. This paper describes a prospective study to determine thereal incidence of aneuploidy for autosomes 13, 16, 18, 21, 22, and gonosomesin preimplantation human embryos obtained from patients with recurrentpregnancy loss after ovarian stimulation in an IVF-ET programme. Our resultsindicate that aneuploidy for the chromosomes analysed are abnormally higher inembryos obtained after IVF from recurrent abortion patients (58%)compared to non-recurrent abortion patients undergoing IVF. Furthermore,monosomies are six times more frequent than trisomies (47 : 8) inpreimplantation embryos from recurrent abortion patients. Based on the presentstudy, preimplantation genetic diagnosis (PGD) of embryos obtained frompatients with recurrent miscarriage could prove advantageous in diagnosingabnormal embryos and selecting normal embryos for transfer.