Abstract:
In recent years a series of widespread outbreaks of acute urinary obstruction has occurred in spring in Merino wethers. Animals involved have been grazing oestrogenic strains of subterranean clover at a time when isoflavone concentrations can be expected to be high. Studies have been made on one property on the relationships between these outbreaks, the pasture isoflavone content, and the urinary excretion of phenolic and other constituents by wethers. A trial group of animals was grazed on a dominant sward of the highly oestrogenic Trifolium subterraneum cv. Dinninup during winter and spring. Isoflavone concentrations in the clover reached a peak in early August. However, since the pasture became highly clover-dominant in September and early October the maximum daily intake of isoflavones probably occurred during this period, which also coincided with the occurrence of maximum concentration and maximum daily excretion of total phenols and acid-precipitable material (APM) in the urine. It is suggested that the sediments causing clinical obstructions at this time of the year may be a direct result of increased excretion of phenols. APM showed a highly significant direct relationship with total phenols but its excretion increased at a greater rate than did that of phenols. Urinary calcium excretion also increased at the same time.